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Buspirone is an anxiolytic drug that is non-sedating and non-habit-forming. Rickels and colleagues report the results of a double-blind pilot study comparing the effects of buspirone and placebo in 34 patients with premenstrual syndrome (PMS). Patients received an average dose of 25 mg of buspirone or placebo during the last 12 days of their menstrual cycle for three consecutive cycles. The authors determined outcomes by evaluating a 17-item diary kept by patients.
Buspirone was significantly better than placebo at alleviating all 17 items measured, including aches and pains, fatigue, cramps, irritability, and impaired personal relationships. The authors conclude that because buspirone is effective and does not cause dependency, it may be an…