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Adequate dietary or supplemental calcium (1000 mg or more daily) is recommended for women who are middle-aged and older. Many calcium supplements are commercially available, but is any single formulation better than another? This crossover study, partially funded by GlaxoSmithKline and coauthored by 2 of its employees, compared the cost, absorption, and pharmacokinetics of the sponsor's oyster-shell-derived calcium carbonate product (Os-Cal®) with those of calcium citrate (Citracal®).
Twenty-four generally healthy postmenopausal women (mean age, 56.1) were assigned a standardized diet and vitamin D supplementation. They received calcium carbonate (503 mg elemental calcium), calcium citrate (516 mg), a laboratory-prepared precipitated calcium…