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Recent evidence suggests that beta-blockers might not be necessary for low-risk patients after a myocardial infarction (MI); however, whether these medications can be safely discontinued in stable patients remains an open question.
To investigate further, researchers enrolled 2500 adults who had been taking beta-blockers for at least 1 year following an MI (mean age, 63 years; 87% men; 57% ST-segment elevation MI) and were in stable condition and without significant left ventricular systolic dysfunction or atrial fibrillation. Participants were randomized to either immediate beta-blocker discontinuation or continuation with the same agent and dose.
Over a median 3 years’ follow-up, the primary composite end point of death, r…