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The ongoing discussion of the potential role of cimetidine in wart therapy continues in a recent series of letters and responses published in the Archives of Dermatology.
One letter reports a study of cimetidine alone versus cimetidine plus topical therapy for treating common warts that failed to respond to other treatments. A group of 40 adults and children were given cimetidine at a dose of 20 to 40 mg/kg per day for four months. The complete cure rate was 10% in the group given cimetidine alone and 35% in those who also received topical treatment. Except in one patient, warts did not progress during therapy. These investigators were not impressed with the efficacy of cimetidine.
A reply to this study contends that the results are not all t…