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Most studies of treatment of acute urinary tract infection (UTI) have been performed in young women, but acute UTI also is common in elderly women. In this randomized, nonblinded, multicenter study (supported by the maker of ciprofloxacin), researchers compared 2 antibiotic regimens in 261 elderly women with UTIs (mean age, 80), about half of whom lived in nursing homes. All patients had both pyuria and UTI symptoms; none had indwelling urinary catheters.
Patients received 10-day courses of ciprofloxacin or trimethoprim-sulfamethoxazole (TMP-SMX) given as oral suspensions. In an intent-to-treat analysis conducted 4 to 10 days after therapy ended, rate of complete clinical response (resolution of symptoms and signs, and no need for alternativ…