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Pronunciation: sip roe FLOKS a sin
BackgroundThe class of antibiotics known as quinolones includes nonfluorinated quinolones, such as nalidixic acid, and fluorinated quinolones, such as ciprofloxacin, gatifloxacin, and levofloxacin. No fluorinated quinolones have been FDA approved for use in children younger than 18 years. Because ciprofloxacin is used for off-label treatment in children, it is important to understand the drug's indications and potential adverse effects.
Mechanism and Spectrum of Action: Ciprofloxacin's mode of action involves binding to topoisomerases 2 and 4 of bacteria, which are necessary for DNA replication. It is active against a wide range of gram-negative organisms, including Pseudomonas aeruginosa, and it has some …