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Nevus depigmentosus (ND) is a nonprogressive hypopigmented macule or patch that remains relatively stable in size and distribution. The clinical and histologic features are not well defined beyond case reports. In infants and children, hypopigmented lesions may be the presenting sign of genetic disorders with serious systemic sequelae, such as tuberous sclerosis and hypomelanosis of Ito with systemic abnormalities. The differential diagnosis also includes vitiligo, a condition with a different prognosis and treatment options. Investigators from Seoul, Korea, examined the clinical characteristics of ND in 67 patients and the histologic features of 18 lesions.
Age at first evaluation was not provided, but lesions were noted at birth in 19.4% o…