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Clinical Takeaway
: A large prospective study confirms dose-dependent, multidimensional hepatoprotective effects.Context
Coffee has many putative health benefits, including protection against liver disease. Researchers now have probed a large British clinical database for a rigorous analysis of this association, following 350,000 adults (mean age, 57) for a median of 13 years. About 80% of participants reported they drank coffee daily in quantities ranging from 1 cup to 5 cups or more.
Key Findings
Coffee consumption was associated with a dose-dependent reduction in risk for incident liver disease, adjusted for alcohol intake and a range of other health and demographic factors:
Compared with people who didn’t drink coffee, those who drank 1 to 2 cups daily had significantly lower relative risks for hepatocellular carcinoma and liver-related death (adjuste…