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A previous, nonrandomized study from Finland showed that among patients with hereditary nonpolyposis colorectal cancer (Lynch syndrome), mortality was significantly lower in those who underwent colonoscopic surveillance at 3-year intervals than in those who were not screened (JW Gastroenterol Jul 1 2000).
To assess the effectiveness of 1- to 2-year surveillance intervals recommended in the Netherlands for Lynch syndrome patients, investigators examined colorectal cancer (CRC) incidence rates in 745 patients (from 205 families) with genetically established Lynch syndrome who had undergone at least two colonoscopies since 1995. Lynch syndrome was identified by mismatch repair gene mutations in MLH1 (75 families), MSH2 (87 families), or MSH6 (4…