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Oxybutynin and tolterodine are the 2 most popular agents for treatment of overactive bladder. In immediate-release preparations, tolterodine is thought to be similar in efficacy to oxybutynin but better tolerated. In this randomized, double-blind study, researchers compared a new extended-release formulation of oxybutynin (Ditropan XL; 10 mg once daily) and immediate-release tolterodine (Detrol; 2 mg twice daily) in 378 patients. The trial was supported by the maker of oxybutynin.
At baseline, subjects reported about 25 episodes of urge incontinence per week. After 12 weeks of treatment, episodes were reduced by 76 percent with oxybutynin and 68 percent with tolterodine, a significant difference (P=0.03). Total micturition episodes (92 per w…