Correction Factor for CSF Protein Levels in Traumatic Lumbar Puncture

Subtract 1.1 mg/dL protein for every 1000-cell increase in CSF red blood cell count.

Traumatic lumbar puncture (LP) is common in children and occurs when the needle causes bleeding into the subarachnoid space. Introduction of peripheral red blood cells (RBCs) in cerebrospinal fluid (CSF) increases CSF protein levels, thereby complicating diagnosis of bacterial meningitis. Investigators examined the association between CSF RBC count and CSF protein level in a prospective cohort of 1298 patients (median age, 3 months; age range, 0 days –23 years) who underwent LP in the emergency department at a children's hospital in Boston and did not have evidence of meningitis. Most LPs were performed to evaluate for possible meningitis.

Overall, 189 patients (15%) had traumatic LPs (CSF RBC count >1000/mm³). CSF protein level increased by…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

Correction Factor for CSF Protein Levels in Traumatic Lumbar Puncture

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Reviewing Author