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Whether cough is a side effect of angiotensin- converting-enzyme inhibitors has been a subject of debate. The authors report 33 cases of cough associated with captopril and 26 cases associated with enalapril.
Cough was common with low doses and did not appear to be dose-related. Women were affected significantly more often than men. Cough was severe enough to warrant withdrawal of the drug in 76 percent of those taking captopril and 88 percent of those taking enalapril. When the drug was withdrawn, the cough disappeared in all patients; no apparent long-term effects were observed.
The authors conclude that cough is a clear-cut side effect of angiotensin-converting-enzyme inhibitors, necessitating withdrawal of treatment in some patients.