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Nonadherence to oral anticoagulants in patients with atrial fibrillation is associated with poor outcomes; however, the adherence threshold below which patients have excess risk for thromboembolic events is unknown. In a population-based study, Canadian researchers analyzed administrative data from 1996 to 2019 (including prescription refills) on 44,000 patients (mean age, 71) who began taking oral anticoagulants after new diagnoses of atrial fibrillation.
The researchers examined the proportion of days on which patients took oral anticoagulants in the 90 days before a primary outcome occurred (i.e., composite of stroke/systemic embolism, transient ischemic attack, or death). Median follow-up was 7 years. At the time that a primary ou…
