Dementia Risk in Patients Achieving Low Diastolic Blood Pressure

Clinical Takeaway

: In patients who achieved systolic BP <130 with treatment, low diastolic BP was not associated with cognitive impairment or dementia.

Context

The J-shaped relationship of blood pressure (BP) refers to the possible link between very low BP and greater cardiovascular risk. Some people have postulated that very low diastolic BP (DBP) increases the risk for adverse cognitive outcomes. To understand the relationship between treated DBP and cognitive function, investigators performed a secondary analysis of the SPRINT-MIND trial.

The analysis included 4400 participants (mean age, 67) who achieved a systolic BP <130 mm Hg with treatment. Investigators adjusted for treatment intensity, demographics, other medication use, and other clinical characteristics.

Key Results

In the fully adjusted model, low on-treatment DBP (<60 or 60–69 mm Hg), compared with DBP 70–79 mm Hg, was not associ…

Reviewing Author

Karol E. Watson, M.D., Ph.D., F.A.C.C.

Disclosures

Consultant/Advisory BoardBoehringer Ingelheim; Amgen; Novartis; Lilly; Amarin

Speaker’s BureauBoehringer Ingelheim

Grant/Research SupportNIH

Editorial BoardsCirculation (Associate Editor)