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It is not uncommon for inclusion body myositis (IBM) to be misdiagnosed as polymyositis (PM), largely because the diagnoses hinge on histopathologic features, and physicians therefore often ignore distinctive clinical features. To examine how histopathologic and clinical features correlate in patients with myositis, these researchers used their own combined biopsy and clinical criteria to reexamine muscle biopsies and clinical records of 107 patients who had initially been diagnosed with PM or IBM.
Of the 107 patients, 64 had IBM, 27 had PM, and 16 had clinical features of IBM but lacked histologic features necessary for confirmation. Thus, 37% of patients (16 of 43) who would have been diagnosed as PM on biopsy alone actually had IBM. Nonne…