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The U.S. FDA has received increasing numbers of reports of depression and suicide in patients using isotretinoin. Though causation is still unproven, new product labeling and informed consent forms have been instituted. The question of isotretinoin-induced depression is complicated by the high baseline incidence of depression and suicide in the adolescent population and by the depression and stress associated with severe acne.
Investigators conducted a cohort study to evaluate changes in depressive symptoms among patients with moderate-to-severe acne who were treated with isotretinoin, compared with patients who received maximal conservative acne therapy. The investigators enrolled patients aged 12 to 19 from hospital-affiliated and communit…