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Although the sedative effects of first-generation antihistamines are well recognized, little is known about their effect on driving performance. This University of Iowa study compared the driving skills of people taking a first-generation antihistamine, a nonsedating antihistamine, and alcohol.
Forty adults were randomized to receive diphenhydramine (50 mg), fexofenadine (60 mg), ethanol (approximate blood-alcohol concentration of 0.1%), or placebo. Using the Iowa Driving Simulator, investigators assessed each driver's ability to follow at a constant distance, to keep to a lane, and to respond to an unexpected hazard. Maintaining a constant distance was affected most by diphenhydramine, and keeping to a lane was affected by both diphenhydram…