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Essential tremor (ET), the most common movement disorder, can lead to functional disability and embarrassment. Pharmacologic treatment with beta-adrenergic antagonists (e.g., propranolol) or primidone is often unsatisfactory due to lack of benefit, adverse effects, or contraindications. Data from open-label studies suggest that gabapentin may have some beneficial effects in patients with ET. In this double-blind, cross-over study, 16 patients with ET (mean age, 68 years) were randomized to three daily doses of gabapentin (400 mg), propranolol (40 mg), and placebo for 15 days with a 1-week washout between treatments. Six patients had never been treated, and 10 patients underwent a 2-week washout prior to enrollment. Outcome measures included…