Endovascular Therapy for Patients with Post-Thrombotic Syndrome

Post-thrombotic syndrome after acute lower-extremity deep venous thrombosis (DVT) is characterized by persistent symptoms and signs of chronic venous insufficiency such as pain, pruritus, edema, and ulceration. This syndrome is especially common and severe after proximal DVT, particularly with iliac-vein obstruction. To find out whether targeted treatment would improve outcomes in these patients, researchers randomized 225 adults with moderate-to-severe post-thrombotic syndrome and image-confirmed iliac-vein obstruction to endovascular therapy (iliac-vein stent and recommendation for ≥6 months of anticoagulants and aspirin) or to no endovascular therapy. Both groups received standard care (e.g., knee-high compression stockings, antic…