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Treatments for patients with hand osteoarthritis (OA) include acetaminophen, nonsteroidal anti-inflammatory drugs, topical therapies, local injections, splints, and surgery. Hand-exercise therapy also is recommended, but few data support its use. In this study from Norway, 80 women (mean age, 61) with hand OA (diagnosed according to American College of Rheumatology criteria) and at least three hand OA–related activity limitations were randomized to a home-based hand-exercise program or an information-only control group. The exercise group was instructed to perform the hand-exercise program () three times weekly (10 repetitions of each exercise during the first 2 weeks, 12 repetitions during the next 2 weeks, and 15 repetitions dur…