FDA Approves OTC Orlistat

The FDA approved an over-the-counter version of the weight loss drug Xenical (orlistat) on Wednesday. The lipase inhibitor will be sold under the name Alli as a 60 mg capsule — a lower dose than the prescription version of the drug.

Alli is meant to be used by adults with a BMI of 27 or more, in conjunction with a reduced-calorie diet and exercise plan. Users can take up to three capsules a day, one with each fat-containing meal, and should take a multivitamin at bedtime, as the drug can block the absorption of some vitamins.

The most common side effects are diarrhea and other changes in bowel habits, which can be reduced by eating a low-fat diet. The drug is contraindicated in transplant recipients. Patients on anticoagulants or who are being treated for diabetes or thyroid disease should only use the product under physician supervision.