Functional Angiography to Guide Complete Revascularization in STEMI

For patients with ST-segment–elevation myocardial infarction (STEMI) and multivessel coronary artery disease (CAD), complete coronary revascularization is the standard of care. However, the best strategy to identify nonculprit vessels to treat with percutaneous coronary intervention (PCI) is unknown. In the open-label, industry-supported AIR-STEMI trial, researchers randomized nearly 2000 participants with STEMI and multivessel CAD within 48 hours of culprit-lesion PCI to either standard angiography or functional coronary angiography (physiology guided) during the index procedure. Complete coronary revascularization was completed prior to hospital discharge. The primary outcome was a composite of all-cause death, myocardial infarctio…