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Cluster headaches are typically sharp, one-sided headaches lasting 15 to 180 minutes, often accompanied by red, watery eyes and nasal congestion. Less common than migraine, their severity is far worse. Investigators conducted a double-blind, randomized, placebo-controlled 8-week study to assess the safety and efficacy of subcutaneous galcanezumab injections for these headaches.
The treatment group had a mean reduction of almost 9 fewer weekly attacks in the first 3 weeks compared with 5 fewer in the placebo group (P=0.04; confidence interval, 0.2–6.7); 71% of galcanezumab recipients and 53% of placebo recipients experienced a reduction of at least 50% in headache frequency at week 3. Both groups had a continued reduction in cluster attacks f…