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Ginkgo biloba is one of the most heavily marketed herbal supplements for cognitive enhancement and dementia prevention. The G. biloba Evaluation of Memory (GEM) study was a randomized, double-blind, placebo-controlled clinical trial assessing the efficacy of G. biloba in preventing dementia and cognitive decline in elders with normal cognition or mild cognitive impairment at baseline. The authors previously reported that G. biloba was ineffective in preventing Alzheimer disease or dementia (JAMA 2008; 300:2253). Now, they report the effect of G. biloba on rates of decline in global cognition, memory, attention, executive function, language, and visuospatial function.
The researchers randomized 3069 community-dwelling elders (mean age, 79) wi…