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Since the late 1950s, griseofulvin has been the treatment of choice for tinea capitis; it is very safe and inexpensive and is available in tablet or liquid forms. The main disadvantages are long treatment duration (6–8 weeks) and erratic absorption. Shorter treatment and longer tissue retention of drug have increased use of newer antifungal agents (terbinafine, itraconazole, and fluconazole) for adult fungal skin infections. These agents, however, are much more expensive, dosage forms are limited, and data regarding pediatric use are few.
Investigators performed a meta-analysis of randomized, controlled trials to compare griseofulvin with terbinafine for tinea capitis treatment in children and adults. Seven studies involving 2163 subjects we…