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Influenza predisposes to acute cardiovascular events that portend significant morbidity and mortality. The high-dose influenza vaccine is more effective at preventing influenza than standard-dose influenza vaccines, but does this superiority extend to severe cardiovascular outcomes, particularly in those with preexisting cardiovascular disease (CVD)? Investigators set out to answer this question with a prespecified pooled analysis of two randomized trials that involved nearly 470,000 older adults (mean age, 73). One quarter had preexisting CVD.
The high-dose vaccine led to modest but consistent reductions in serious cardiovascular outcomes compared with the standard-dose vaccine, including a 7% reduction in cardiovascular h…