ICD Survival Benefit Comes with Some Risk for Incident Heart Failure

MADIT-II data provide insights about the magnitude of the HF risk and about which patients with ICDs are most susceptible.

Implantable cardioverter-defibrillators (ICDs) prolong survival in a broad range of patients with LV systolic dysfunction (LVSD), as documented in multiple trials including MADIT-II (Journal Watch Cardiology May 3 2002). However, the risk for new or worsening heart failure (HF) in MADIT-II was greater with ICD therapy than with conventional medical therapy. These researchers assessed the risk factors for, and outcomes after, incident HF in that trial.

All 1232 MADIT-II subjects had LV ejection fractions ≤30% and had experienced MI at least 1 month before enrollment. Of the 715 ICD recipients with available follow-up data and known ICD type, 56% received single-chamber ICDs and 44% dual-chamber devices. On average, subjects with dual-chamber …

Reviewing Author

Frederick A. Masoudi, MD, MSPH

ICD Survival Benefit Comes with Some Risk for Incident Heart Failure

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Reviewing Author