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These authors examined the relationship between granular deposits of IgA in the papillary dermis and the presence of cutaneous lesions of dermatitis herpetiformis.
In the initial phase of the study, biopsies were performed on lesional, perilesional, and never-involved skin of 19 patients with dermatitis herpetiformis. IgA deposition was more frequent and more intense in perilesional skin than in lesional skin, and was seldom seen in never-involved skin. Similar findings were observed with C3 deposits. In the second phase of the study, biopsies from perilesional and non-involved skin from the same anatomic regions were taken from each of 15 patients. In 80% of patients, IgA deposition was more pronounced in perilesional skin than in never-inv…