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The term lupus pernio was coined by Besnier to describe potentially scarring facial lesions of sarcoidosis that often occur in conjunction with systemic manifestations and have traditionally been difficult to treat. High doses of corticosteroids are effective but are associated with steroid-related toxicity. Therefore, the search for corticosteroid-sparing agents is ongoing.
These researchers retrospectively studied 54 patients with a diagnosis of lupus pernio from a single sarcoidosis clinic. They excluded patients whose choice of therapy was driven by systemic disease, those who made a single clinic visit, those with inactive cutaneous disease, and those for whom data were unavailable. The patients had been photographed at each clinic visi…