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Selective serotonin reuptake inhibitors (SSRIs) have broad clinical applications because serotonin (5HT) controls diverse psychobiological functions mediated by at least seven major receptors. This diversity of action may create unexpected interactions with other serotonergic substances. This report suggests that past LSD may create such an interaction.
Ten months after stopping chronic LSD use, an 18-year-old female experienced prolonged flashbacks after beginning 50 mg/day of sertraline for depression and again after a single dose of paroxetine. When the SSRIs were withdrawn, the flashbacks stopped, and her depression responded to psychotherapy.
The second patient, a 17-year-old male, had used LSD regularly for several years without flashba…