Interaction Between SSRIs and NSAIDs? Now It's Missing

Unlike a previous study, this one shows that NSAID use does not affect antidepressant response.

In a 2011 examination of preclinical and clinical data (JW Psychiatry May 2 2011), researchers suggested that nonsteroidal anti-inflammatory drugs (NSAIDs) interfere with the antidepressant efficacy of selective serotonin reuptake inhibitors (SSRIs) through a specific interaction with the serotonin receptor. To further examine this interaction, the current researchers analyzed the effect of NSAIDs on the antidepressant efficacy of escitalopram (10–30 mg/day) and nortriptyline (50–200 mg/day) in 811 patients with major depression who were enrolled in a partially randomized clinical and pharmacogenetic study that had received some industry support.

Seventy-eight patients (10%) were taking NSAIDs, and 59 (7%) were taking analgesics. Use of anal…

Reviewing Author

Jonathan Silver, MD

Disclosures

RoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions

Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience

Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)

Jonathan Silver, MD

Disclosures

RoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions

Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience

Interaction Between SSRIs and NSAIDs? Now It's Missing

Topics

Reviewing Author