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Ketorolac tromethamine has commonly been administered parenterally for the treatment of pain in the emergency department, although the frequency of this practice is declining. To determine whether ketorolac reduces fever, researchers prospectively randomized a convenience sample of 43 noncritical, febrile (temperature >38.0°C) adult patients to receive either intravenous ketorolac (0.5 mg/kg; maximum dose, 30 mg) or an equivalent volume of saline. They recorded oral temperature every 15 minutes for 1 hour.
Two patients in the ketorolac group and one in the placebo group became afebrile before the study drug was administered and were excluded from the analysis, leaving 20 patients in each group. One patient in the ketorolac group complained o…