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In a 2009 meta-analysis of 8282 children undergoing ketamine sedation in the emergency department, investigators identified risk factors for airway and respiratory adverse events, including 22 occurrences (0.3%) of laryngospasm, defined as “stridor or other evidence of airway obstruction that did not improve with airway alignment maneuvers” (Ann Emerg Med 2009; 54:158). Now, the investigators performed a case-control analysis on the same dataset to assess predictors of ketamine-associated laryngospasm.
Each of the 22 case patients (median age, 3.7 years) was matched to 4 controls by American Society of Anesthesiologists (ASA) physical status ≥3 vs. <3, oropharyngeal procedure, ketamine dose, route of ketamine administration (intravenous vs. …