Loading...
Two studies were performed to determine whether lansoprazole and esomeprazole -- 2 proton-pump inhibitors (PPIs) -- have differences in clinical healing and symptom resolution in patients with erosive esophagitis. Interestingly, these 2 similar studies reached very different conclusions.
Howden and colleagues randomized 284 patients with erosive esophagitis (grade 2 or higher) to receive lansoprazole (30 mg daily) or esomeprazole (40 mg daily) for 8 weeks. Healing rates at 4 weeks were 77.0% for lansoprazole and 78.3% for esomeprazole; at 8 weeks, corresponding rates were 91.4% and 89.1%. There were no significant differences between agents in symptom resolution. These authors concluded that the 2 agents were equivalent.
Castell and colleague…