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In 2005, Barry Coller wrote a prescient article in which he reviewed the evidence showing that an elevated leukocyte count was a risk factor for ischemic vascular disease (Arterioscler Thromb Vasc Biol 2005; 25:658). He cited many examples of the association of leukocytosis with acute thrombosis, including high white blood cell (WBC) counts associated with myocardial infarction mortality and stroke severity, and high leukocyte counts in sickle-cell patients who developed ischemic vascular complications. Now, the European Collaboration on Low-dose Aspirin in Polycythemia vera (ECLAP) group reports that leukocytosis is a risk factor for thrombosis in essential thrombocythemia (ET).
The investigators recorded age, sex, blood counts, JAK2 mutati…