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Treatment with ACE inhibitors has been shown to reduce progression of nephropathy in type 1 diabetes. In this study, the EUCLID (EURODIAB Controlled Trial of Lisinopril in Insulin-dependent Diabetes Mellitus) investigators examined whether lisinopril at a dose of 10 to 20 mg/day can reduce the progression of diabetic retinopathy in type 1 diabetic patients without hypertension or advanced albuminuria.
Of 530 patients randomized to lisinopril or placebo, retinal photographs at baseline and at 24 months were available for 179 placebo and 175 lisinopril patients. The average age was 34 years and the average blood pressure was 123/81 mm Hg in each group. Approximately 15 percent of all patients had microalbuminuria. Retinopathy progressed by one…