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Several investigations have suggested that aspirin provides some protection against migraine headaches, but these studies have been limited to small numbers of patients. Researchers from the Physicians' Health Study -- best known for its findings on aspirin's protective effects against cardiovascular disease -- have analyzed their data on other diseases occurring among the 22,071 male physicians in the study and found evidence that supports the migraine hypothesis.
Among physicians who were randomized to receive low-dose aspirin (325 mg every other day), 6 percent reported migraine headaches during the five years after randomization, as compared with 7.4 percent of those assigned to the placebo control group. Rates of reported ordinary heada…