Low, Standard, and High Doses of IVIg for Maintenance in CIDP

All three doses used in this randomized trial were safe and effective, and a dose-dependent response was suggested.

This industry-sponsored, international, randomized trial tested the safety and efficacy of lower (0.5 g/kg), standard (1.0 g/kg), and higher (2.0 g/kg) dose intravenous immunoglobulin (IVIg) for maintenance in treating chronic inflammatory demyelinating polyneuropathy (CIDP). Participants previously treated with corticosteroids (87.1%) or IVIg (12.9%) were included. Corticosteroids and IVIg were reduced to the lowest dose causing deterioration in a washout phase. One hundred and forty-two patients received 2.0 g/kg induction IVIg and were randomized 1:2:1 to receive 0.5 g/kg, 1.0 g/kg, or 2.0 g/kg IVIg every 3 weeks for 24 weeks. The primary outcome was response rate in the standard-dose group, defined as an improvement of ≥1 point in adjus…

Reviewing Author

Leana Doherty, MD

Disclosures

Editorial BoardsNeurohospitalist Society; InterACTN (Annals of Clinical and Translational Neurology)

Leana Doherty, MD

Disclosures

Editorial BoardsNeurohospitalist Society; InterACTN (Annals of Clinical and Translational Neurology)

Low, Standard, and High Doses of IVIg for Maintenance in CIDP

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Reviewing Author