Can We Manage Thyroid Nodules without Surgery?

Clinical Takeaway

: Percutaneous laser ablation of benign thyroid nodules significantly and safely reduced their size.

Context

Benign thyroid nodules are treated if they cause compressive symptoms, or if they secrete excess thyroid hormone (toxic nodule). Treatment is typically surgical resection, but less-invasive methods are increasingly sought.

In this retrospective study, 1500 patients (including 200 with a toxic thyroid nodule) who had received percutaneous laser ablation for benign thyroid nodules were followed for up to 10 years.

Key Results

Nodule volume decreased by ≥50% in all patients, and median reduction in volume was 70% at 1 year.
80%–90% of patients had improvement in compressive symptoms or cosmetic effects.
Most patients with toxic nodules were able to reduce the dose of methimazole or stop it altogether.
The procedure was associated with mild co…

Reviewing Author

Ole-Petter Hamnvik, M.B. B.Ch. B.A.O., M.M.Sc., M.R.C.P.I.

Disclosures

Consultant/Advisory BoardMerck

Editorial BoardsEndocrine Practice

Leadership Positions in Professional SocietiesWorld Professional Organization for Transgender Health (Co-lead, Curriculum Development Committee)