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Patients with severe mental illness are at increased risk for venous thromboembolism (VTE) because of reduced mobility, medical comorbidities, antipsychotic use, and lifestyle factors such as smoking. Whether mechanical restraint adds to this risk has been uncertain (). To learn more, investigators conducted a population-based study using Danish registry data and two complementary designs.
A cohort study included more than 24,000 adults admitted to psychiatric hospitals and exposed to mechanical restraint or chemical restraint (active comparator).
At 30 days, VTE was twice as common after mechanical than chemical restraint (3.5 vs. 1.7 per 1000 patients; number needed to harm, 548). Longer mechanical restraint durati…