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The 2004 American College of Obstetricians and Gynecologists guidelines on nausea and vomiting in pregnancy specify use of intravenous (IV) dimenhydrinate, metoclopramide, or promethazine as first-line agents for dehydrated women with hyperemesis gravidarum (HG). In an intent-to-treat, randomized, double-blind trial, researchers assessed 24-hour outcomes in 149 Malaysian women who were admitted to a university hospital and treated for HG with IV promethazine (25 mg every 8 hours) or metoclopramide (10 mg every 8 hours). Participants recorded episodes of vomiting and reported well-being on a visual numerical rating scale.
Perceived well-being and frequency of vomiting did not differ significantly between groups. Certain adverse effects were m…