Loading...
Approximately three million women in the United States are infected with Trichomonas vaginalis each year. Although oral metronidazole is an effective treatment for trichomoniasis, the high frequency of adverse effects can compromise patient adherence to the regimen. In addition, some cases of trichomoniasis are resistant to oral metronidazole, and use of the agent in early pregnancy is controversial. This multicenter, randomized, open-label pilot study investigated the safety and efficacy of an alternative to oral metronidazole, metronidazole vaginal gel, for the treatment of trichomoniasis.
Fifty-six women were randomized to receive either 0.75% metronidazole gel (5 g twice daily) or oral metronidazole (250 mg three times daily). Regimens l…