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Concerns about the teratogenic potential of metronidazole have prompted a search for other effective drugs to treat bacterial vaginosis. This randomized, multicenter European trial compared 1 week of oral metronidazole (500 mg twice daily) with 1 week of 2 percent clindamycin vaginal cream (once daily) in nonpregnant women. Each group concurrently took a placebo to mimic the opposite treatment.
Although 407 women were enrolled, only 229 had complete follow-up evaluations at 25 to 39 days. All others were excluded from the efficacy analysis for reasons such as noncompliance, loss to follow-up, or return visits made at the wrong time. At 1 week, 85 percent of evaluable women taking clindamycin were clinically cured or improved, versus 87 perce…