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"The tongue of man is a twisty thing" -- Homer
Ehlers-Danlos syndrome (EDS) comprises a group of inheritable connective tissue diseases. The diagnosis is based on such clinical findings as hyperelastic skin and hypermobile joints. Other cutaneous signs are atrophic "cigarette paper" scarring, tongue hypermobility (Gorlin's sign), eyelid extensibility (Metenier's sign), easy bruising, subcutaneous nodules, pseudotumors, and postural acrocyanosis, but these findings are not present at birth, and clinical diagnosis can be frustratingly delayed. These Italian investigators looked for developmental abnormalities of the oral frenula in patients with EDS. They examined 12 adults who met the criteria for a diagnosis of classical EDS (type II, mitis)…