Multifocal Motor Neuropathy: What Have We Learned?

Multifocal motor neuropathy (MMN) is an immune-mediated disorder characterized by slowly progressive, asymmetric, predominantly distal weakness without sensory loss. Van Asseldonk and colleagues comprehensively review the clinical, pathologic, immunologic, and electrophysiologic studies that have improved our understanding of MMN since its original description in 1985.

Among numerous salient points covered, the authors:

• review the clinical features of MMN;

• highlight the important clinical distinctions among MMN, lower motor neuron disease, and other demyelinating neuropathies, notably chronic inflammatory demyelinating polyneuropathy and the Lewis-Sumner syndrome;

• propose a set of detailed clinical, laboratory, and electrophysiologic (primarily…