International Genetics Groups Call for Cautious Approach to Gene Editing

By Amy Orciari Herman

Edited by André Sofair, MD, MPH, and William E. Chavey, MD, MS

An American Society of Human Genetics working group has issued a position statement urging a "cautious but proactive approach" to germline genome editing.

Among the group's conclusions, published in the American Journal of Human Genetics:

• "It is inappropriate" to perform germline gene editing that ends in a human pregnancy, given the numerous outstanding questions regarding the science and ethics of such editing.

• In vitro germline editing on human embryos and gametes is acceptable "to facilitate research on the possible future clinical applications of gene editing." Public funding for such research should not be prohibited.

• Human germline genome editing should not be used clinically unless there's a "compelling medical rationale," good evidence of its benefits, and an "ethical justification."

The working group comprised representatives from several international genetics associations, including the UK Association of Genetic Nurses and Counsellors and the Canadian Association of Genetic Counsellors. A total of 11 international genetics groups endorsed the statement.