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To test the century-old theory of arterial dilation as the cause of migraine, researchers studied spontaneous attacks in 19 patients with migraine without aura using magnetic resonance angiography. The primary endpoints were comparisons of the circumference of the extracranial and intracranial vessels between attack-free days and during attacks, and between brain hemispheres ipsilateral and contralateral to the pain. The authors examined both extracranial arteries (external carotid, superficial temporal, middle meningeal, and cervical internal carotid arteries) and intracranial arteries (cavernous and cerebral internal carotid, middle cerebral, and basilar arteries).
The circumferences of the extracranial vessels and the basilar artery did n…