Natural History of Combined Aortic Stenosis and Aortic Regurgitation

In a prospective case series, event rates were high and unrelated to baseline severity of disease, but aortic jet velocity was a reliable predictor of outcome.

Lacking evidence-based management strategies in patients with both aortic stenosis (AS) and aortic regurgitation (AR), clinicians often follow guideline recommendations for the more-severe disorder. However, this approach has not been validated. To find out more, investigators prospectively studied disease progression and outcomes in 71 consecutive asymptomatic patients (mean age, 52; 30% women) with mixed AS and AR of at least moderate severity.

About half of the patients had bicuspid valves. At baseline, mean peak aortic jet velocity (AV-Vel) was 4.31 m/sec, and mean aortic valve area was 0.98 cm². During long-term follow-up (mean, 8.9 years), 50 patients (71%) developed indications for aortic-valve replacement, including symptoms, progres…

Reviewing Author

Howard C. Herrmann, MD

Disclosures

Consultant/Advisory BoardAffluent Medical; Artedrone; Caranx; Johnson & Johnson; Medtronic; Prolifagen; Wells Fargo

EquityMicrointerventional Devices, Inc.

RoyaltiesUniversity of Pennsylvania

Grant/Research SupportAbbott Vascular; Edwards Lifesciences; Johnson & Johnson; Medtronic

Editorial BoardsCatheterization and Cardiovascular Interventions; Journal of the American College of Cardiology; Circulation: Cardiovascular Interventions; JACC Cardiovascular Interventions; JACC Case Reports; JSCAI

Leadership Positions in Professional SocietiesHeart Valve Collaboratory (Scientific Committee Member, Chair of the Publications Committee)