Among HIV-infected MSM with no prior history of high-grade anal intraepithelial neoplasia, 30% were found to have it on high-resolution anoscopy–guided biopsy.
Risk for anal cancer is higher in HIV-infected men who have sex with men (MSM) than in the general population, and incidence appears to be increasing. As part of a study to evaluate the safety and immunogenicity of a quadrivalent human papillomavirus (HPV) vaccine in HIV-infected men, investigators screened HIV-infected MSM who did not have a history of anal or perianal cancer, high-grade anal intraepithelial neoplasia (HGAIN), or either high-grade squamous intraepithelial lesions (HSILs) or atypical squamous cells suggestive of HSIL on anal cytology at any point prior to screening. Anal swabs were taken for HPV testing and cytology, and high-resolution anoscopy (with biopsies on visible lesions) was performed.
The analysis involved 235 men …
Reviewing Author
DisclosuresGrant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; NIH/National Institute on Drug Abuse
Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes; Vaccines
Leadership Positions in Professional SocietiesInternational Antiviral Society–USA (Board of Directors); Infectious Diseases Society of America (Past President)
DisclosuresGrant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; NIH/National Institute on Drug Abuse
Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes; Vaccines
Leadership Positions in Professional SocietiesInternational Antiviral Society–USA (Board of Directors); Infectious Diseases Society of America (Past President)