B-Cell Lymphomas in HIV/HCV-Coinfected Patients

HIV-monoinfected patients have an increased risk for B-cell non-Hodgkin lymphoma (NHL) — most commonly, high-grade malignancies such as diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma. Several studies have suggested that hepatitis C virus (HCV)-monoinfected patients may also have an increased risk for NHL. To understand whether HCV coinfection influences the types of lymphomas seen in HIV-infected patients, investigators in France examined a series of tumors found in HIV/HCV-coinfected and HIV-monoinfected patients.

Forty-one HIV-monoinfected patients and 6 HIV/HCV-coinfected patients with NHL were enrolled in a prospective study between 2007 and 2009. At the time of NHL diagnosis, HIV RNA was undetectable in 4 of the 6 coinfected…